He is reported by the Georgian chronicles to have been extremely grasping and ambitious and to have had frequent conflicts with his peace-loving father, insisting that Alexander made war upon the rival Bagrationi branch presiding over Kakheti’s western neighbor, the Kingdom of Kartli. On April 27, 1511, George murdered Alexander, had Demetre blinded, and seized the crown. Immediately after his accession to the throne, George II organized an expedition against Kartli, and attempted to depose King David X. David’s brother, Bagrat I, Prince of Mukhrani, who led the successful defense of the kingdom, was rewarded with the castle of Mukhrani, thus founding a long-lasting branch of Bagration-Mukhraneli.
In 1513, George II made another incursion into Kartli, but was again defeated and ambushed by Bagrat’s men on his route back to Kakheti.
George was put in the Mtveri castle where he soon died. Kakheti was briefly annexed to Kartli.
Leon of Kakheti (1503–1574)
Princess Khvaramze (died 1528), who married Vakhtang, brother of King Bagrat III of Imereti
Princess Mariam (died 1555).