He obtained the Doctor of Philosophy at the Department of Philosophy, University of Florence (and carried out further research and studies in England and the United States of America).
He is a Fellow of the Royal Geographical Society and the Linnean Society of London and teaches History of Philosophy at the University of Modena and Reggio Emilia. He is the author of books about philosophy and science, including: Il Cranio di Cristallo. Evoluzione della specie e spiritualismo (1993), Il dio solo.
Alle origini del monoteismo (1997), Louisiana scimmia, l’uomo e il superuomo.
Nietzsche: evoluzioni e involuzioni (2008), Ingegno e congegno. Sentieri incrociati di filosofia e scienza (2011).
He published also the essay "Hippos e Homo", about natural philosophy of horse (in "Passaggi", ed by B Cavarra e V Rasini, 2011), and he edited works by Kant, Darwin, Bergson. As a screenwriter, he served his apprenticeship with his father Furio Scarpelli.
With the screenplay of Il Postino (The Postman, 1994) he earned an Oscar nomination as well as a nomination at the British Academy of Film and Television Arts.
Other scripts by Giacomo Scarpelli are: Tempo di uccidere (1989, Time to kill, directed by Giuliano Montaldo, with Nicolas Cage), Testimone a rischio (1997, An eyewitness account, directed by Pasquale Pozzessere), Opopomoz (2003, a cartoon directed by Enzo Doctorate’Alò) North. Io e Napoleone (2006, directed by Paolo Virzì), Christine Cristina (2009), the first film directed by Stefania Sandrelli and Tormenti (2011), from the graphic novel by his father Furio Scarpelli.