Background
Klopman, Gilles was born on February 24, 1933 in Brussels, Belgium. Came to the United States, 1965. Son of Alge and Brana Klopman.
Klopman, Gilles was born on February 24, 1933 in Brussels, Belgium. Came to the United States, 1965. Son of Alge and Brana Klopman.
Bachelor, Athenee d"Ixelles (Belgium), 1952. Licensed chemistry, U. Brussels, 1956. Doctorate.Chemistry, 1960. Research scientist Cyanamid European Research Institute, Geneva, Switzerland, 1960-1967.
Postdoctoral fellow University Texas, 1964-1965.
Associate professor Case Western Reserve University, Cleveland, 1967-1969, professor.chemistry, 1969, department chairman, 1981-1986, interim dean science and mathematics,1986-1988, Chaplain to the Forces Mabery professor of research, department chairman, 1988-1995. Vice president Biofor, Limited., Pennsylvania, 1986-1995.
President Discovery Software Incorporated., 1991-1993, Multicase, Incorporated., 1995.
Professor Klopman’s work has involved the evaluation of chemical reactivity and includes experimental determination of reactivity indices and substituent constants to the development of reactivity theories. He has contributed significantly to the concept of charge and orbital controlled reactions where his work is widely used to explain the ambident selectivity of nucleophiles and links the linear free energy type correlations to more fundamental chemical concepts. In the field of quantum mechanics and computers he has designed and programmed the first semi-empirical method for the calculation of the properties of saturated molecules that later became known as MINDO. His work also encompasses problems of artificial intelligence and its general use to correlate biological data and he has been involved in developing software to represent and manipulate chemical data.
Lately his efforts have focused primarily on the determination of quantitative structure activity relationships in both carcinogenic and chemotherapeutic agents, consisting of developing computer simulations of the actions of drugs, seeking correlations between the chemical structure of the drugs and their activity in order to produce better antitumor agents.
His work has also helped to develop quantitative relationships between the nature and intensity of odors and their chemical structure for the perfume industry. (adapted from the CWRU website for the Department of Chemistry listed below).
Member American Chemical Society (Morley medal 1993), British Chemical Society Belgium Chemical Society (Stas Spring medal 1960), Swiss Chemical Society, American Association of University Professors, Sigma Xi.
Married Malvina Pantiel, September 5, 1957.