He entered public life as administrative secretary and administrative director, 1961. In the following year he was sent as Ambassador to London, March 1962-January 1964, from where he returned to take up the post of technical adviser at the Ministry of Foreign Affairs in Bamako.
Enjoying at the time the full confidence of President Modibo Keita, he was transferred in September 1966 to the important post of Secretary of State in charge of Rural Economy, Power Supply and Animal Industries. From December 1967 he became a member of the National Committee for the Defence of the Revolution, Keita's supreme political organisation, until the November 1968 military coup d’etat.
Sow became Secretary-General at the Ministry of Foreign Affairs and Cooperation in the provisional government set up by the military junta in November 1968. Appointed Ambassador to Ghana three years later, he arrived in Accra on October 8, 1971.