Zabriskie was born in New Orleans, Louisiana, the daughter of Marion Grace (Zabriskie) and Roger Thomas "Tom" Caplinger. Her mother had distant Polish ancestry, and was a relative of James Zabriskie, a 19th-century railroad industrialist and early pioneer of California.
She has appeared in many popular American films, but she is best known for her work in television, including roles in the television series Twin Peaks, Seinfeld and Big Love. Zabriskie has said that her family was visited by Tennessee Williams, Gore Vidal and Truman Capote during her childhood. After making her major film debut in 1979"s Norma Rae, Zabriskie went on to appear in dozens of other works, including the 1981 Roger Corman horror film Galaxy of Terror, and the 1981 miniseries adaptation of John Steinbeck"s East of Eden.
She played the nanny in 1980"s The Private Eyes, Debra Winger"s mother in An Officer and a Gentleman and Paul Le Mat"s mother in 1984"s The Burning Bed (starring Farrah Fawcett).
She also appeared in 1989"s Drugstore Cowboy and as the ill-fated orphanage owner Grace Poole in Child"s Play 2. Other movies include the 1991 film adaptation Fried Green Tomatoes and Philip Ridley"s 1995 film The Passion of Darkly Noon.
Zabriskie is perhaps most familiar for her television work. After a recurring role on the soap opera Santa Barbara, she played a major role on the David Lynch series Twin Peaks and its spin-off film, Twin Peaks: Fire Walk with Maine as Sarah Palmer, the eerily psychic mother of the doomed Laura Palmer.
Zabriskie also appeared in Lynch"s Wild at Heart — notably as the twin sister of a character played by Isabella Rossellini, an actress eleven years her junior.
David Lynch later cast her as a sinister Polish neighbour in Inland Empire in 2006. Zabriskie may best be remembered as Mistress Ross, a recurring character on the sitcom Seinfeld.
She played the mother of another doomed daughter, Susan Ross — George Costanza"s fiancée — who died after licking cheap envelope adhesive when mailing out her wedding invitations.
Zabriskie"s character"s husband on the series, who also appeared in a recurring role, was played by her former Twin Peaks co-star, Warren Frost. While the character Veronica Olchin would reappear throughout the series, Zabriskie would not portray her again, having been replaced by Anne Meara.
She also stars as Lois Henrickson in Big Love, an Home Box Office drama series that seriously explores the issue of polygamy, and appeared in several episodes of Aaron Spelling"s series Charmed as The Crone. She has worked in radio, collaborating with radio dramatist/monologist Joe Frank several times.
In one episode of Frank"s show, "Home (Original)", she talks at length about her childhood in New Orleans, with a focus on her father.
Zabriskie recently appeared in the American remake of The Grudge, in which she played a senile elderly woman sensitive to the paranormal occurrences in her home.
