Natale took a three-year course in interior design at the Enmore Design Centre at Technical and Further Education NSW – Sydney Institute, studied visual arts at Sydney College of the Arts, and architecture at the University of Technology, Sydney. This was around the end of the minimalism movement, and Natale chose to pursue a more luxurious look than had previously been in style.
From 1996 to 2001, Natale worked for three different architectural design firms: Garth Barnett Designers, Home Box Office+EMTB, and SJB. In 2001, he launched Greg Natale Design. His first major project was the 2002 design of the Gonano Apartment, with a decorative, repeat pattern coordinated on walls, blinds, bed linens and art Based in Sydney, the firm handles interior design in residential, retail and commercial spaces, and also does residential exterior design.
Natale"s style is a mixture of opulence, vibrant colors, patterns and textures, with meticulously curated and balanced, layered spaces and modern touches.
He has designed products including rug collections of commercial and domestic rugs and carpets for Designer Rugs, wallpaper collections for Porter"s Paints, furniture collections for Stylecraft and Regency Distribution, and a range of tiles for Teranova Tiles. Natale has twice been named the Belle / Coco Republic Interior Designer of the Year.
He was a keynote speaker at the 2013 Australian International Furniture Fair, and has appeared as a guest judge on the reality television shows The Renovators and homeMADE. Natale"s first book, The Tailored Interior, was published by Hardie Grant in November 2014, with photography by Anson Smart and a foreword by Jonathan Adler. The book offers insights and lessons on interior design, including Natale"s philosophies and approach to paint color, type of paints, patterns, proportion, cohesion and layering, showcasing 18 spaces Natale has created.