Doctor of Medicine, University Heidelberg, Germany, 1970. Doctor of Philosophy in Physiology, University Heidelberg, Germany, 1978. Doctor (honorary), Ludwig-Maximilians University, Munich, 1999.
Researcher Institute Pharmacology, University Gothenburg, Sweden, 1972-1973, Institute Physiology, University Heidelberg, 1971, lecturer physiology, 1973—1983, chair vegetative physiology, 1980—1983. Head department cardiovascular pharmacology Schering AG, Berlin, 1983-1987, director Institute Pharmacology, 1987-1989, member executive board, 1989—2005. President Union German Academies Sciences & Humanities, since 2008.
Board directors German Council of Scientific & Humanities, since 1992. Member supervisory board Charité–University Medicine Berlin, since 2006, Jerini AG.
Chairman board trustees Max Plank Institute Molecular Genetics, Humboldt University, Berlin. Vice chairman board trustees Central European University, Budapest. Member medical board Austrian Science Council.
Member of Max Planck Society Advancement of Science (vice president 2001), Academia Europaea, German Academy of Sciences Leopoldina (senator 1999—2003), European Academy of Sciences & Arts, Berlin-Brandenburg Academy of Sciences (president since 2006).