Carruthers is best known for her work in Keystone comedies. Helen"s career began in 1914. She appeared in thirty-five Keystone comedies, seventeen of which were alongside Charlie Chaplin.
Her film debut was in the Chaplin comedy, His Favourite Pastime.
Her last work for Keystone was as Chaplin"s love interest and the King"s wife in His Prehistoric past Her acting career seemingly ended in 1915.
In May 1915, Helen, aged just twenty-three, attempted suicide. She swallowed thirty mercury bichloride tablets, causing severe damage to her kidneys.