He was educated at Harrow School and Corpus Christi College, University of Oxford gaining an Master of Arts in Law and was called to the bar at Lincoln"s Inn in 1879.
Seton-Karr owned a cattle ranch (Pick Ranch) in Wyoming, United States of America and was a director of Capitol Freehold Land and Investment Company He was an explorer, big game hunter and writer He did not stand again in Street Helens, but at the January 1910 general election he stood unsuccessfully in Berwickshire.
Seton-Karr died in Canada"s greatest maritime disaster when the Empress of Ireland sank in the Saint Lawrence River when he was returning to England from a hunting trip in British Columbia.
He was interred at the Mount Hermon Cemetery, Sillery. On 11 November 1880 Seton-Karr married Edith Eliza Pilkington (1860-1886), daughter of William Roby Pilkington and Elizabeth Lee Watson of Roby Hall, Liverpool.
They had three children: George Bernard (12 September 1881), Malcolm Henry (born 21 October 1882) and Edith Muriel (born 1884). Both George and Edith Muriel died in their teens.
They had two children: Helen Mary (born 6 October 1888) and Kenneth William (born 21 March 1897).
23rd United Kingdom Parliament. 24th United Kingdom Parliament. 25th United Kingdom Parliament.
26th United Kingdom Parliament.
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Seton-Karr was elected as the Member of Parliament (Member of Parliament) for Street Helens in the 1885 general election and held the seat until his defeat at the 1906 general election.