Hilda Bruce

Background

Hilda Bruce was born on 5 April 1903.

Education

She was educated at Street Leonards School.

Career

Her work on the control of fertility earned her the Oliver Bird Meda In 1923, she began her tertiary studies at King"s College for Women, where she received a Bachelor of Science in Household and Social Science, and another in Physiology. In 1928, Bruce joined the National Institute for Medical Research at Mount Vernon, Hampstead.

Her early research was dedicated towards the understanding of Vitamin Doctorate. She also jointly published the first article describing the breeding characteristics of the golden hamster.

In 1933, Bruce was employed by the Pharmaceutical Society, where she continued her research on Vitamin Doctorate. In 1941, she was appointed to set up the Cod Liver Oil (Poultry) Standardisation Laboratory.

In 1944, she returned to the NIMR, where she formulated specialised diets for laboratory animals. From the early 1950s, Bruce turned her attentions towards sexual behaviour in rodents, particularly the Whitten effect. In 1959, she published her discovery of what is now called the, the termination of pregnancy following exposure to the scent of an unfamiliar male.

Bruce retired from the NIMR in 1963, but continued part-time research, variously on nutrients, development and pheromones, at the Department of Investigative Medicine in Cambridge.

She continued work at the Department until 1973. In her later years, Bruce largely used a wheelchair, having been afflicted with worsening rheumatoid arthritis since 1942.

Throughout the 1950s, Bruce studied sexual behaviour in laboratory mice, with a particular interest in oestrus synchronisation. In one experiment, she housed newly mated pregnant females with male mice that were not the father of the carried embryo.

As a result, the rate of miscarriages increased, these females subsequently returning to oestrus and mating with the new male.

Number increased rate of miscarriages occurred when pregnant mice were paired with juvenile or castrated mice. Following the isolation of pure vitamin Doctorate in 1931, Bruce worked in collaboration with Askew, Philpot and Webster in the Department of Biological Standards, determining the stability of the pure substance. At this time, Bruce was also working with Doctor Callow in the Department of Physiology, Pharmacology and Biochemistry, determining the healing effect of vitamin Doctorate in rats with rickets.

Connections

colleague:

Alan Parkes