Career
He has an extraordinary record in his political career, as he was elected mayor three times and was also unseated the same number of times because of the electoral protests filed by his rivals. Saquilayan was elected as vice mayor in 1998 and served until 2001, when he decided to challenge incumbent Mayor Oscar Jaro in his reelection bid. He defeated Jaro by only 748 votes.
In the elections that year, he and Jaro challenged each other again and defeated the latter by about 1,000 votes.
He and Jaro would run against each other for the third time that year but Jaro withdrew from the race and endorsed Vice Mayor Emmanuel Maliksi instead. He was defeated by Maliksi in that race.
In 2010, he was elected again as mayor, winning over Maliksi by a margin of 8,499 votes. However, on April 11, 2013, it reversed its ruling and remanded the case back to the COMELEC. This upcoming 2016 elections, former City Mayor Homer Saquilayan decided to run as 3rd District Provincial Board Member under the United Nationalist Alliance.