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Horace Green was born on December 24, 1802, in Chittenden, Vermont. He was the youngest of the nine children of Zeeb and Sarah (Cowee) Green.
His father, a soldier in the Revolution, was descended from Thomas Green who emigrated to Massachusetts Bay about 1635. Among his ancestors also were a number of physicians and apothecaries.
Green studied medicine with his brother, Dr. Joel Green of Rutland, attending at the same time the Medical School at Middlebury (known later as Castleton Medical College), where he received his M. D. degree in 1825.
After graduation, he formed a partnership with his brother but had an opportunity in the winter of 1830-31 to visit Philadelphia and attend medical lectures there.
In 1835, he removed to New York City, where with the exception of several brief interruptions, he practiced until the end of his life.
He spent several months in Europe in 1838, when he came under the influence of Louis, but he did not remain long enough to learn Louis’s painstaking methods.
At first, Marshall Hall, the English physiologist, was skeptical of Green’s claims about the value of applying solutions of silver nitrate locally in catarrhal inflammation of the pharynx and larynx, but then he became convinced after seeing experiments carried out upon the larynx of dogs.
So rancorous were the attacks on Green that he was compelled to resign from one New York medical society and narrowly missed expulsion from the Academy of Medicine, but in spite of this professional jealousy he built up a large practice.
From 1840 to 1843, he was a professor of medicine and president of Castleton Medical College, and in 1850, he became one of the founders of the New York Medical College, where he was also a professor of medicine, occupying the chair until his retirement in 1860. In 1854, he founded the American Medical Monthly, which was, however, short-lived.
He spent the winters of 1863-64 and 1864-65 in Cuba for his health, and died at his country residence at Sing Sing (Ossining), New York.
Green is remembered chiefly for the acrimonious controversy which arose in 1846 after the publication of his Treatise on Diseases of the Air Passages: Comprising an Inquiry into the History, Pathology, Causes and Treatment, of those Affections of the Throat called Bronchitis, Chronic Laryngitis, Clergyman’s Sore Throat. It was the first systematic work ever published on that subject and went into a fourth edition in 1858. In pointing out the value of applying solutions of silver nitrate locally in catarrhal inflammation of the pharynx and larynx he made a fundamental contribution. He contributed extensively to medical journals and was the author of Observations on the Pathology of Croup (1849) and of a Practical Treatise on Pulmonary Tuberculosis, embracing its History, Pathology and Treatment (1864).
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Green’s seemingly innocuous statement that it was possible to introduce a probing into the larynx and in this way apply local medication was attacked furiously, his opponents characterizing the procedure as not only quite impracticable but dangerous to life (the laryngoscope had not yet been invented).
Unfortunately, Green had laid himself open to criticism by saying that medication applied in this way would cure a great variety of intractable pulmonary and laryngeal diseases, tuberculosis among them. His knowledge of pathology was not wholly sound, being probably based upon the imperfectly comprehended teachings of Louis.
In the department, Green was urbane and kindly.
Green was married twice; on October 20, 1829, to Mary Sigourney Butler of Rutland, Vermont, who died August 17, 1833; and on October 27, 1841, to Harriet Sheldon Douglas of Waterford, New York. He had one child by his first wife, and ten by his second.
