After attending the University of Michigan, he became, in 1901, a news writer (soon after, feature writer) for the Detroit Journal. Between 1903 and 1905, he was a sports writer for Chicago and Detroit newspapers. He joined the Associated Press in 1906.
Between then and 1916, he was a bureau chief in New Orleans, Atlanta, and Dallas.
He was news editor in Chicago from 1916 to 1926, then moved to New York where, after two years as photo service editor, his title became Science Editor, Associated Press"s first. Blakeslee reported extensively on the atomic bomb in the immediate post-war era and was among the group of reporters who witnessed the early tests at Yucca Flat.
Also interested in the subject of atomic power, his book publications include Miracle of Atomics (1945), The Atomic Future (1946), and Atomic Progress: The Hydrogen Race (1951). The Howard West. Blakeslee Award of the American Heart Association is named in his honor.
Blakeslee and Rosamund had three children: Howard, Rosamund, and Alan.
Sandra"s son Matthew Blakeslee is also a full-time science writer, thus representing the fourth generation of Howard Blakeslee"s notable science-reportorial dynasty. Howard Blakeslee died in 1952, shortly after returning from return a visit to the atomic bomb testing site in Nevada.