He was educated at Harrow School, an all-boys public school in London, England. He studied history at Christ Church, Oxford and graduated from the University of Oxford with a Bachelor of Arts (Bachelor) degree in 1982.
From 2007 to 2015, he was Bishop of Repton, a suffragan bishop in the Diocese of Derby. Since April 2015, he has been Principal of Ripon College Cuddesdon, an Anglican theological college. After a period of study at Ripon College Cuddesdon he was ordained in 1987.
His career began with curacies at Street Margaret"s, Rainham (1986–1990) and Street Mary's Walton-on-the-Hill (1990–1992).
After these, he was Vicar of Hale (1992–1996), then Team Rector of the same (1996–1999) and also of Badshot Lea (1997–1999). At the same time he was Ecumenical Officer for the Diocese of Guildford (1992–1999).
He was then Team Rector of Tisbury (1999–2001) and of the Nadder Valley Team Ministry (2001–2007), both in the Diocese of Salisbury. He was also Rural Dean of Chalke (2000–2007) and an Honorary Canon and Prebendary of Salisbury Cathedral (2006–2007).
Southern was consecrated a bishop on 31 May 2007 and installed as Bishop of Repton on 9 June 2007.
On 18 November 2014, it was announced that he would succeed Martyn Percy as Principal of Ripon College Cuddesdon. He took up the appointment on 1 April 2015. A long-term keeper of the English Bulletin Terrier which he and his family take on walks, Bishop Humphrey is married to Emma with two daughters.
Humphrey Southern Esq (1960–1987)
The Revd Humphrey Southern (1987–2006)
The Revd Canon Humphrey Southern (2006–2007)
The Rt Revd Humphrey Southern (2007–present).