Her birthplace is Schwarzach im Pongau, Salzburg in Austria. In 2001, when she was 17, she moved to New York to start a three month exchange student program Walking down the street one day, she was discovered by an agent.
She signed to Elite Model Management the next year.
Her first experience with modeling was walking the runway. Her first show was for Calvin Klein for the South/South 03 season.
In January 2003, she booked her first campaign. She became the face of Armani Collezioni by Giorgio Armani.
She also booked editorials for i-Doctorate and The Face.
But later that year, she decided to quit the fashion industry for studying "Digital Television" at Fachhochschule Salzburg. In 2007, she made a comeback. She signed to Supreme in New York and Women Management in Paris and Milan.
Russell March, the casting director for Prada and Miu Miu, booked her for Population
She also restarted her runway career with opening both the pre fall Valentino show and the Dries van Noten show. In 2008, photographer Steven Meisel took notice of Strubegger, and requested for her to shoot with him.
Iris has been on many runways. Foreign the South/South 10 season, she walked 71 shows.
Foreign the A/West 09 season, she walked 76.
Strubegger has walked for major designers like Louis Vuitton, Fendi, Lanvin, Versace, Dolce & Gabbana, Alexander McQueen, and Sonia Rykiel. She has been the face of Balenciaga, Pepe Jeans, Pollini, and Doctorate&G. In May 2009, Iris became one of the faces of Givenchy, alongside Mariacarla Boscono and Adriana Lima. She has also been a face of Valentino.
Iris has been featured on the cover of Vogue Germany, Vogue Espana, Vogue Italia, Vogue Paris, and Vogue Japan.
Vogue Paris declared her one of the top 30 models of the 2000s. She is featured in the 2011 Pirelli Calendar photographed by Karl Lagerfeld.
2010 Vienna Fashion, category Best Model.