Career
He is credited as being the oldest company commander in the Mexican War. Ferguson died in Mexico City on January 1, 1848. He was succeeded by his second in command, First Lieutenant Ephraim M. Daggett.
Isaac was buried in Mexico City with a United States flag draped around him.
A bill sent to his widow, Elizabeth, translated from Spanish, says "In the City of Mexico, January 3, 1848, died the Seňor, Captain Isaac Ferguson, and in order to bury him, I made a casket the value of the lumber and iron ornaments (hardware), eight pesos ($4) and six reales (75c) and also four reales of lumber to cover the casket and six more to launder his clothes." Signed, Marcos Villa.