Career
Manuel had the powerful backing of the megas domestikos (commander-in-chief of the army) John Axuch who took control of the capital before Isaac learned of his father"s death and could make any bid for the throne. Axuch was faithful to the wishes of John II, although he is recorded as having tried hard to persuade the dying emperor that Isaac was the better candidate to succeed. Although some of the clergy, the people and the military, thought that Isaac was better fit to rule, he had to resign himself to his younger brother"s accession.
In 1145–1146 he campaigned with him against the Seljuk Turks in Anatolia.
Although the relationship between the brothers remained uneasy, there was never an open conflict, and Isaac enjoyed the court dignity of sebastokrator. The marriages of Isaac"s daughters served as useful tools of Manuel"s foreign policy.
Alexios Komnenos (d c 1136). Ioannes Komnenos (d c 1136/7).
Eirene Komnene, who married an unnamed Doukas Kamateros and became the mother of Isaac Komnenos of Cyprus.
Anna Komnene, who married before 1166 Constantine Makrodoukas (d 1185). Maria Komnene, who married in 1156 King Stephen IV of Hungary.