She was the daughter of Alice of Champagne and Hugh I of Cyprus, and the sister-in-law of Plaisance of Antioch, queen of Cyprus who married her brother. Henry was son of Count Henry I of Champagne and Marie of France, Countess of Champagne, daughter of Louis VII of France and Eleanor of Aquitaine.
She was also Regent of the Kingdom of Jerusalem. Amalric was son of Hugh VIII of Lusignan. Eschive was daughter of Baldwin of Ibelin.
Henry drowned at sea on June 18, 27 or 28, 1276.
Their descendants took the surname de Lusignan. They had two children:
Hugh, King of Cyprus and Jerusalem
She was appointed de facto regent of Jerusalem at Acre in 1263 and in turn she appointed Henry bailli of the kingdom.
Isabella died in 1264, sometimes after the February, she was buried at Nicosia. Isabella"s husband, Henry drowned at sea off Tyre in June, 1276 while sailing to Tripoli in a German ship.
