Career
With several Marranos he sailed from Portugal in a vessel which was driven out of its course to Emden in East Friesland. After his arrival there, he confessed the Jewish faith openly, and afterwards, though advanced in years, underwent the rite of circumcision. Together with Jacob Israel Belmonte and Samuel Palache, Tirado founded the Spanish-Portuguese community of Amsterdam, being its first president
Having acquired a house on the Houtgracht, he transformed it into a synagogue, which was called after him "Bet Ya"akob," or "Casa de Jacob," and was consecrated at the Jewish New Year"s festival (September 1597).
Annually on Yom Kippur a special prayer in his behalf is recited as an acknowledgment of his important services to the community. In his old age Tirado traveled to Jerusalem, where he died.