Background
He was born at Modena in 1477, the son of a noted jurist.
He was born at Modena in 1477, the son of a noted jurist.
He obtained the patronage of Cardinal Carafa and adopted the ecclesiastical career. Pope Leo X chose him as his secretary along with Pietro Bembo, and in 1517 made him bishop of Carpentras.
A faithful servant of the papacy in many negotiations under successive popes, especially as a peacemaker, his major aim was to win back the Protestants by peaceful persuasion and by putting Catholic doctrine in a conciliatory form. Sadoleto was a diligent bishop, made cardinal in 1536, given the titular church of San Callisto.
In 1539 Cardinal Sadoleto wrote to the people of Geneva, urging them to return to the Catholic faith. John Calvin had been asked to leave Geneva the previous year, and was living in Strasbourg, but the Genevans still asked Calvin to write a response to Sadoleto, which he did.