Born in Guise in Picardy, he began his studies at Paris, completed a course of philosophy and theology before he was eighteen years of age, and then, at the request of his parents went to Orléans and later to Poitiers to study jurisprudence.
But having no inclination for law, he devoted most of his time to literature. Quietly withdrawing to Lyon and later to Avignon, de Billy devoted himself, for a period, entirely to the study of Greek and Hebrew. After some hesitation de Billy accepted them, then entered the Order of Saint Benedict, and later was made a regular abbot.
Thenceforth he led a very ascetic life and governed his monasteries with great prudence.
He was especially solicitous for the proper observance of monastic discipline and with that object in view renewed, in 1566, the statutes of his predecessor, Abbot Bertrand de Moussy. During the civil wars that devastated France at this period the monastery of Saint-Michel-en-l"Herme was wholly destroyed.
The abbot himself was frequently obliged to seek refuge from the ravages of war, and resided, for short periods, at Laon, Nantes, Paris, and in the Priory of Taussigny. His Anthologia sacra libri quator, quorum primus & secundus a Jacobo Billio..Tertius Prosperi Aquitanici sacra Epigrammata in Doctorate. Aurelii Augustini sententias continet.
Quartus varios Hymnos sacras, pietatem spirantes complectitur was first published in Paris in 1575.
He died at Paris.
