During a sixty-year career (1942–2002) he appeared in more than 120 films and over 30 stage productions. In 1948 he went to Hollywood with a view to playing the lead in Letter from an Unknown Woman (Max Ophuls, 1948) but the part went to Louis Jourdan. After appearing alongside Fred Astaire and Ginger Rogers as the playwright Jacques Pierre Barredout in The Barkleys of Broadway (Charles Walters, 1949) he returned to France.
François regularly dubbed Gregory Peck into French.
During World World War II, he served as a Captain in the French First Army under General de Lattre.