Background
Phipps was born in Berkeley Parish to a poor, landless labourer working as Jenner"s gardener.
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James Phipps
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Career
Jenner knew of a local belief that dairy workers who had contracted a relatively mild infection called cowpox were immune to smallpox. He was baptised in Street Mary"s parish church, Berkeley, when he was 4. On 14 May 1796 he was selected by Jenner, who took "a healthy boy, about eight years old for the purpose of inoculation for the Cow Pox".
Jenner took some fluid from the cowpox vesicles on the hand of a milkmaid named Sarah Nelmes (in an unpublished manuscript Jenner refers to her as Lucy Nelmes), and inoculated Phipps by two small cuts in the skin of the boy"s arm.
Jenner wrote: On the seventh day he complained of uneasiness in the axilla and on the ninth he became a little chilly, lost his appetite, and had a slight headache. During the whole of this day he was perceptibly indisposed, and spent the night with some degree of restlessness, but on the day following he was perfectly well.
About six weeks later Jenner inoculated the boy with smallpox which had no effect, and concluded that he now had complete protection against smallpox. Phipps was subsequently inoculated with smallpox more than twenty times without succumbing to the disease.
Phipps is often cited incorrectly as the first person to be vaccinated against smallpox by inoculation with cowpox: other people had undergone the procedure before him.
In 1791, Peter Plett from Kiel in the Duchy of Holstein (now Germany) inoculated three children and Benjamin Jesty performed the procedure on three family members in 1774. However, Jenner included his description of the vaccination of Phipps and an illustration of the hand of Sarah Nelmes from which the material was taken in his Inquiry published in 1798. Together with a series of vaccinations which showed that the vaccine could be maintained by arm to arm transfer, and information about selection of suitable material, Jenner"s Inquiry was the first published account of vaccination.
Phipps attended Jenner"s funeral on 3 February 1823.
By today"s standards of medical ethics, Jenner"s human experimentation on James Phipps is untenable. lieutenant is, however, one of the milestones of modern medicine.
