Career
Kaczmarek has appeared in over forty television roles, the most notable including:
Nurse Sandy Burns on St. Elsewhere (1982).
Connie Lehman in The Paper Chase: The Second Year (1983–1984)
Maureen Culter, girlfriend of Martin Crane (John Mahoney) on Frasier in "Police Story" (052–1996) and "Dad Loves Sherry, the Boys Just Whine" (082–1997)
Janet Rudman on Law & Order in "Censure" (414–1994)
Carol Anderson, biological mother of Julie Emrick on Felicity in 5 episodes (1999–2000)
Holly in five episodes of Cybill (1996–1997)
Helene Thompson in three episodes of Party of Five (1995–1999)
Lois, mother of Malcolm (Frankie Muniz), Reese (Justin Berfield), Francis (Christopher Masterson), Dewey (Erik Per Sullivan), and baby Jamie, and wife of Hal (Bryan Cranston) in 151 episodes of Malcolm in the Middle from 2000 to 2006
Trudy Kessler, Courtroom Judge in 25 episodes of Raising the Bar from 2008 to 2009
The voice of Judge Constance Harm in eight episodes of The Simpsons between 2001 and 2010, namely "The Parent Rap", "Brawl in the Family", "Barting Over", "Brake My Wife, Please", "The Wandering Juvie", "On A Clear Day I Can't See My Sister", "Rome-old and Juli-eh", and recently "Chief of Hearts".