Career
He arrived in Cape Town on 5 September 1831, where he stayed at Wamakersvallei (Wellington) for two months, to learn Dutch, and from where he departed to Kuruman to do mission work among the Tswana people (Zeerust). He later named the mission station Bethulie (meaning Eloah – house of God). The land of the mission station was transferred to the Paris Mission Society in 1836.
Besides his mission work, Pellissier made a great contribution towards practical education and medicine among the local people.
In 1861 he was officially acknowledged as a medical practitioner by the local government of the Orange Free State.