He belonged to the important Enríquez family, whose title Duque de Medina de Río-Seco was awarded by King Charles I of Spain, Emperor Charles V, in April 1538. He was politically exiled from Spain by siding with Archduke Charles, later Emperor of the Holy Roman Empire Charles VI of Austria (1685–1740) in the War of Spanish Succession. They had no surviving issue.
After his wife"s death, he remarried in 1697 with her niece, Ana Catalina de la Cerda y de Cardona-Aragon, (1663–1698), widow since 1690 of Pedro Antonio de Aragón 5th Duke of Segorbe, Viceroy of Naples !664 – 1671, and daughter of Juan Francisco de la Cerda (1637–1691), 8th Duke of Medinaceli, 6th Duke of Alcalá de los Gazules, Knight of the Order of the Golden Fleece in 1670, Prime Minister of King Carlos II of Spain and many other lesser titles, and Catalina Antonia de Cardona-Aragon y Sandoval, 9th Duchess of Cardona, 8th Duchess of Segorbe on her own rights.
He was the 11th and last hereditary Admiral of Castile, Governor of the Duchy of Milan, (1678–1686), Viceroy of Catalonia, (1688), member of the State Council, ambassador in Rome and France, Caballerizo mayor to the King and Field Marshal of the Holy Roman Empire (1705).
