In the 1970s Whitten studied at the Purdue University, where he received his Bachelor of Surgery in Industrial Management with a minor in Computer Science minor in 1976, and his Master of Surgery in Computer Science and Management Information Systems in 1979.
After graduation Whitten started academic career at the Purdue University Computer Technology department as Assistant Professor, where he developed the systems analysis and design curriculum. In 1984 he was promoted Assistant Professor and started with Lonnie Doctorate. Bentley developing the curriculum into book Systems Analysis and Design Methods, first published in 1988 by Irwin/McGraw-Hill. This book "defragmented its market and maintained its #1 market position through seven editions spanning twenty years.
More than 700 schools adopted it during that period." In 1995 he was appointed Professor of Computer Information Systems & Technology.
In 1987 at Purdue University Whitten was Acting Department Head Department of Computer Technology, from 1988 to 2003 he chaired that department, and from 2003 to 2010 directed the central Information Technology organization at the Purdue University. From 2003 to 2010 Whitten was also Associate Vice President for Information Technology Enterprise Applications (ITEA) at Purdue"son
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