He attended Notre Dame High School in Sherman Oaks, California where he was known as a class clown and an avid basketball fan.
He is the creator and star of the YouTube channel "LifeAccordingToJimmy", which has approximately 2.4 million subscribers and 300 million video views. Tatro has starred in Grown Ups 2, 22 Jump Street, and Blue Mountain State: The Rise of Thadland. He will also appear in the film Camp Manna alongside Gary Busey, set to be released in 2016.
He started making comical videos with friends after receiving his first video camera while attending the University of Arizona.
He dropped out of school his junior year. Tatro performs stand-up across the country at comedy clubs and college campuses.
Tatro"s career segued onto the silver screen in 2013 with a minor role in the Adam Sandler comedy Grown Ups 2. He then co-starred opposite Jonah Hill and Channing Tatum in 2014"s 22 Jump Street as Rooster.
In 2015, he appeared in the film adaption of Blue Mountain State.
Tatro will star alongside Gary Busey in the Christian Summer Camp comedy, Camp Manna, set to be released in 2016. Tatro"s character, Clayton Vance, is described as "the epitome of Christian cool, Clayton Vance is the counselor every kid wants to be. He only loves one thing more than the Lord… himself.
Leader of the Righteous Regiment cabin, his alarming charisma and pedigree for "winning souls" makes him the envy of everyone.
As of March 2016, the channel has over 2.48 million subscribers. Tatro"s vidoes have had numerous celebrity appearances, including: Angela Kinsey, David Henrie Alexander Ludwig, Emily Osment, Milo Ventimiglia, Riff Raff, and Liliana Mumy.
In 2014, his YouTube channel was listed on New Media Rockstars Top 100 Channels, ranked at #92.
Tatro attended the University of Arizona, and is a member of the Pi Kappa Phi Fraternity.