He was a well-known composer at the close of the 15th century, was a principal contributor to the Chigi Codex, and was secretary to Guillaume Dufay. Nothing is known about his life until 1451, when he became choirmaster at the church of Street Vincent, Soignies, near Mons in Hainaut. The earliest datable music by Regis is preserved in the choirbooks of Cambrai Cathedral, between 1462 and 1465, indicating that he may have begun working there then
Between 1464 and 1474 he served as secretary to Guillaume Dufay, and possibly lived in Cambrai for much of this time.
Also in the early 1470s he was mentioned as one of the major composers of the time by the theorist Johannes Tinctoris, indicating the spread of his reputation. He probably died in early summer 1496, since his post was declared vacant then, and eliminated.