Ganzel batted and threw right-handed. He played with the Pittsburgh Pirates (1898), Chicago Cubs (1900), New York Giants (1902) New York Highlanders (1903–1904) and the Cincinnati Reds (1907–1908). Ganzel managed the Reds in 1908 and the Federal League"s Brooklyn Tip-Tops in 1915.
He hit the first ever Yankee home run on May 11, 1903.
A native of Kalamazoo, Michigan, Ganzel came from a family of baseball mentor In a seven-season career, Ganzel was a.251 hitter with 18 home runs and 336 runs batted in during 747 games played.
As a manager, he posted a 90–99 record for a.476 winning percentage. Following his major league career, Ganzel managed several minor league clubs.
In 1938 he headed the Orlando franchise of the Florida State League and was active with the club until his retirement in 1952.
Ganzel died in Orlando, Florida at the age of 84. Led National League first basemen in putouts (1,421), fielding percentage (986) and total chances (1,519) in 1901
Led American League first basemen in fielding percentage (988) and total chances (1,497) in 1903
Led National League in triples (16) and fielding percentage (990) in 1907
While managing in the International League he was, at one time, the highest paid minor league manager, earning $7,000 and a part of the profits.