Background
Skeffington was the eldest son of Sir William Skeffington, 1st Baronet of Fisherwicke, Staffordshire and his wife Margaret Dering of Surrenden Kent.
Skeffington was the eldest son of Sir William Skeffington, 1st Baronet of Fisherwicke, Staffordshire and his wife Margaret Dering of Surrenden Kent.
He matriculated from Jesus College, Cambridge in spring 1603 and was admitted at the Middle Temple on 30 October 1604. He was knighted in August 1624. He succeeded to the Baronetcy on the death of his father in 1635.
From 1637 to 1638 he was Sheriff of Staffordshire.
He supported the Royalist cause in the English Civil War and was fined £1,152 in November 1650, which was reduced later to £961. Skeffington died at the age of about 60 and was buried at Skeffington, Leicestershire, on 20 November 1651.
Skeffington married Cicely Skeffington of Skeffington.
2nd Parliament of King Charles I]
In 1626, he was elected Member of Parliament for Newcastle-under-Lyme.