Career
He has played Sherlock Holmes on the radio drama The Classic Adventures of Sherlock Holmes & The Further Adventures of Sherlock Holmes longer than any other actor in history, including Basil Rathbone. Lowrie has notably performed roles in video games such as The Suffering and The Suffering: Ties That Bind, Total Annihilation and its expansions, The Operative: Number One Lives Forever and Number One Lives Forever 2: A Spy in H.A.R.M."s Way, and Valve games Half-Life 2, Half-Life 2: Episode One, Half-Life 2: Episode Two, Left 4 Dead and Dota 2. He is noted for playing the roles of Agent Gray in the MMORPG The Matrix Online, Odessa Cubbage in Half-Life 2.
Lowrie plays Sherlock Holmes in The Further Adventures of Sherlock Holmes, a radio show produced by Jim French Productions.
In 2011, he published a science fiction novel named Dancing with Eternity.