The eldest son of Nicholas Lysaght and Grace, daughter of Colonel Thomas Holmes of Kilmallock, County Cork, John was educated at Trinity College, Dublin. His father Nicholas was a Protestant landowner in southern Ireland, a soldier he served with William III"s invading Orange army at the Battle of Boyne in 1689 as a Colonel of Horse.
The enusing row in the House of Commons precipitated the fall of the Earl of Strafford, and the opening conflict of English Civil War the following year. They had five children. John Lysaght, 2nd Baron Lisle
Joseph married Henrietta, widow of John Godsell and eldest daughter of 1st Viscount Doneraile.
He died without heirs in 1799.
James died unmarried
Margaret married William Hodder of Huddersfield, Yorkshire
Mary married Kingsmill Pennefather, Member of Parliament for Cashel, eldest son and heir of Richard Pennefather of New Park, County Tipperary.
John Lysaght sat as a Member of the Irish House of Commons for Charleville from 1727 until 1758, when on 18 September he was raised to the Peerage of Ireland as Baron Lisle, of Mountnorth in the County of Cork.
