He served as king"s attorney for Virginia from 1766 until he left for Britain at the outset of the American Revolution. They had three children. In 1774, he wrote "Considerations on the Present State of Virginia", in which he called for reconciliation between his fellow colonists and Great Britain.
When hostilities began, Randolph fled to Scotland with Governor Dunmore.
In Scotland, Randolph continued to promote reconciliation between Great Britain and the colonies. When Randolph died in Brompton, London, in 1784, his last request was to be buried in Virginia.