He was educated in Illinois public schools and received his Bachelor of Arts degree in 1921 from the University of Michigan at Ann Arbor, Michigan. He obtained further education at the University of Chicago, the University of California, Berkeley, and the University of Heidelberg in Heidelberg, Germany, before receiving his Doctor of Philosophy in 1937 from Louisiana State University at Baton Rouge.
His doctoral dissertation is entitled "The Evolution of Louisiana Parishes in Relation to Growth and Distribution in Population."
From 1921-1923, Kyser served a year each on the faculty of Louisiana State University and Tulane University in New Orleans. He headed the Department of Social Sciences from 1924 until May 15, 1954, at which time he was elevated to the presidency of the institution, then known as Northwestern State College. Along with several other four-year institutions in the state, NSU was elevated to university status in 1970, when Kyser"s successor, Arnold R. Kilpatrick, was serving as the NSU president
In 1935, Kyser organized and developed the first statewide field study-tours with college cartulary-register
He was a pioneer of audio-visual education and was instrumental in the development of first closed-circuit television instruction program in Louisiana. Kyser also launched the first graduate program in any four-year state institution of higher education below the level of Louisiana State University. Such programs are now widespread.
Kyser was the chairman of the Geography Section of the Southwestern Social Sciences Association. He was a president of the North Louisiana Historical Association and in 1960 headed the Louisiana Historical Association.
On September 8, 1924, Kyser married the former Thelma Zelenka (1898–1998) of Houma, the seat of Terrebonne Parish in south Louisiana.
She was a daughter of Doctor Rudolph Louis Zelenka and the former Eva Bazet. The couple had one child, Janet (born 1929). Thelma Kyser died ten days before her 100th birthday.
Kyser died in Shreveport, Louisiana.
His papers are located at the Eugene P. Watson Memorial Library on the NSU campus. A tribute to Kyser is found in a 1975 issue of North Louisiana History.
Kyser Hall, which houses the department of history at NSU, is named in his honor.