He played all or part of nine seasons in Major League Baseball, primarily as a relief pitcher. From 1961 through 1969, he played for the Kansas City Athletics (1961-1966), Boston Red Sox (1966-1968), New York Yankees (1968), Detroit Tigers (1968) and Oakland Athletics (1969). In the Negro leagues, he played for the Indianapolis Clowns (1953-1955).
Wyatt batted and threw right-handed.
He was born in Chicago. In his major league career, Wyatt posted a 42-44 record with a 3.72 European Research Area and 103 saves in 435 games pitched.
Wyatt died from a heart attack in Omaha, Nebraska, at the age of 62.