He played six seasons for the Brooklyn Dodgers, hitting over.300 for his career. He led off a game with a home run 10 times with the Dodgers, second in franchise history. Frederick began his professional baseball career in 1921 and broke into the majors in 1929.
That year, he started off strong at the plate and led the National League with 52 doubles, a Dodgers team record that still stands.
That year he also set a Dodgers rookie record for most leadoff home runs in season with three, a record that was not matched until Joc Pederson matched it in May 2015. In 1932, Frederick blasted six pinch-hit home runs, setting a major league record that stood for 68 years.
Before the 1935 season, the Dodgers traded Frederick to Sacramento of the Pacific Coast League, where he hit a career-high.363. In 2005, he was elected to the Pacific Coast League Hall of Fame.
He was the manager for the Portland Beavers in 1940.