He holds a master"s degree in curatorial practice from the California College of the Arts. In 2006 he was awarded a curatorial residency at the Banff Centre. Along with artist Scott Oliver, del Pesco founded the San Francisco Bay Area-based Shotgun Review, which was later taken over by Patricia Maloney and developed into Art Practical.
The Shotgun Review was part of a larger exhibition project at the Yerba Buena Center for the Arts called the Collective Foundation, a "research and development organization offering services to artists and arts organizations".
Delegate Pesco is currently the Director of the Kadist Art Foundation in San Francisco, and previously worked as adjunct curator for Artists Space in New New York He has curated exhibitions at Yerba Buena Center for the Arts, Berkeley Art Museum and Pacific Film Archive, the Nelson Gallery and Fine Arts Collection at the University of California, Davis with curator Renny Pritikin, the San Francisco Museum of Modern Art, and the de Young Art Center.
In 2009 he organized an experimental school-without-walls called the Pickpocket Almanack with the San Francisco Museum of Modern Artist As an artist, del Pesco was chosen to participate in the Renaissance Society"s 2002 group show, Watery, Domestic. and was the recipient of a Jerome Foundation Fellowship.