Antoine Frédéric Spring was a German-born, Belgian physician and botanist.
He studied botany and medicine at the University of Munich, obtaining his PhD in 1835 and his medical doctorate during the following year.
From 1839 to 1872 he was a professor at the University of Liège, initially in the fields of physiology and anatomy, later teaching classes in pathology and internal medicine. As a botanist he specialized in research of Lycopodiaceae (clubmosses) and Selaginellaceae (spikemosses), and was the binomial author of numerous species from both families. His personal herbarium is now kept in the herbarium at the University of Liège.