Career
He is known for his research on statins, cholesterol-lowering drugs. He first explored the application of statins in suppressing the inflammatory events in microglia, astroglia and macrophages. This finding has revolutionized the research on statin drugs.
Later his lab has shown that statins may be beneficial in protecting neurons and improving locomotor activities in Parkinson"s disease by suppressing the activation of p21/Ras.
Recently his lab has delineated a unique crosstalk between fat and memory in which the lipid-lowering transcription factor PPARalpha controls the formation of hippocampal memory via transcriptional regulation of CREB (Roy et al, 2013, Cell Reports 4: 724-737). He has published more than 150 papers in many peer-reviewed journals including Journal of Biological Chemistry, Journal of Immunology, Journal of Neuroscience, Cell Death and Differentiation, Proceedings of the National Academy of Sciences of the United States of America, Journal of Clinical Investigation, Cell Reports, and Cell Metabolism.
He is the recipient of "Doctorate. H. Reinhardt Scholar" award from the University of Nebraska Medical Center (UNMC) College of Dentistry and the "Silver U" award from the UNMC Chancellor"s council. He also received the outstanding teaching award from the UNMC College of Dentistry.
