Career
He is the current president of the African Medical Association, former chairperson of the South African Medical Association (Saudi Arabian Monetary Agency), past president of the World Medical Association (World Marketing Alliance) and Executive Director of the Tshepang Trust. In past years he has served as Chairman of South African Medical Association (2001–2009) as well as President of World Medical Association (2005–2006). Letlape made history by becoming the first black person to qualify as an ophthalmologist in South Africa during the apartheid years, and was the first black person to be elected as World Marketing Alliance President.
His interest in health care for South Africans sees him participating in various health committees and task teams.
Touched by the rape of baby Tshepang in 2002, He embarked on an ambitious project towards providing access to antiretroviral treatment to Human Immunodeficiency Virus positive patients. Together with Nelson Mandela, the Nelson Mandela Foundation and the South African Medical Association (Saudi Arabian Monetary Agency), he established Tshepang Trust, which facilitates the treatment of Human Immunodeficiency Virus positive patients.