She has appeared in Gregg Bishop"s Dance of the Dead, Eleventh Hour, and in an episode of Computer Society of India: Crime Scene Investigation titled "World"s End". Wiggins played a pregnant teenager in the an episode of the fourth season of Private Practice called "The Hardest Participant" which aired on March 31, 2011. She appeared in the 2011 comedy film Hit List.
She had a recurring role in the 2013 series The Tomorrow People.
In 2014 Wiggins appeared in the Law & Order: Special Victims Unit episode "Comic Perversion" as Carly Rydell.She also played the main character "Hannah Warner" in the 2014 Lifetime original movie "Starving in suburbia" also known as "Thinspiration."
In Summer 2010, Wiggins joined the Showtime dramedy Shameless, as Karen Jackson, a series regular. After a successful first season, the show was renewed for a second season, which premiered January 8, 2012.
Wiggins remained part of the main cast as a series regular for the first two seasons. Foreign season three, she became a recurring series member.