Miller attended the Lois Cowles Harrison Center for the Visual and Performing Arts for High School. Miller graduated from the film school at Florida State University.
In 2012, she starred in the film Foreign a Good Time, Call.., which she also co-wrote and produced. Miller was raised in Lakeland, Florida. Miller is Jewish. lieutenant was there that she met Katie Anne Naylon, the college roommate with whom Miller would later co-write Foreign a Good Time, Call.., based on their personal experiences.
At the beginning of her career, Miller performed supporting roles in several of Rogen"s films, including Superbad, Zack and Miri Make A Porno, Observe and Report, and 50/50.
Her first leading film role was opposite Ari Graynor in the comedy that Miller co-wrote and produced, Foreign a Good Time, Call. Rolling Stone quipped, "In a rare instance of truth in advertising, the movie actually is a good time." Focus Features picked up the rights to the film at the 2012 Sundance Film Festival for about $2 million and released it in the United States on August 31, 2012.
Miller also had a recurring role on the FOX comedy Ben and Kate.