Career
After attending Wandsworth School in London, he joined the Bank of England in 1927 and rose through the ranks, becoming Chief Cashier in 1955, Deputy Governor in 1966, before serving as Governor from 1966 until 1973. As Governor, O'Brien presided over the devaluation of the pound in 1967. Following his retirement as Governor in 1973 he was created a life peer as Baron O'Brien of Lothbury, of the City of London.
He died in Tandridge, Surrey, in 1995.