In 1900, Levi Yitzchak married Chana Yanovski, whose father, Rabbi Meir Shlomo, was the Rabbi of the Ukrainian city of Nikolaiev. He was later to become the Rebbe of Lubavitch. Schneerson lived in Nikolaiev until 1909, when he was appointed to serve as the Rabbi of Yekatrinoslav.
In 1939 he was arrested by the communist regime for his fearless stance against the Party"s efforts to eradicate Jewish learning and practice in the Soviet Union, and particularly for distributing Matzah to the Jews of Yekatrinoslav.
After more than a year of torture and interrogations in Stalin"s prisons, he was sentenced to exile to a remote village Chiali in Kazakhstan. Shortly before his death, Levi Yitzchak was able to move to Almaty, where he was warmly welcomed by the small Lubavitcher community.
There he died on the 20th of Av, 5704 (1944). Rabbi Levi Yitzchak was buried at a cemetery in Almaty.
Schneerson was a distinguished Kabbalist.
Some of his writings have been published in a five volume set under the name Likkutei Levi Yitschok.