She played the younger version of the female lead in the 2014 film The Best of Maine and starred in the 2010 films, Trust and The Last Sin Eater. In 2005, Liberato made her acting debut in the television series Cold Case and has appeared on the Sons of Anarchy, Computer Society of India: Miami and House Doctor of Medicine. She also made an appearance in the music video for Miley Cyrus"s song, 7 Things. The following year she appeared in the fourth season of House and was featured in the June issue of The New York Times Magazine.
In 2007 Liberato obtained the leading role in the 20th Century Fox adventure film The Last Sin Eater.
2010 found Liberato starring in the film, Trust. In June, she was cast in the film Trespass.
She played the younger version of the female lead in the 2014 film The Best of Maine.