Career
At 16 years of age, he moved to Rome. He wrote biographies of contemporary artists, and those of Perugia. The former, published in Rome in 1730, is an important source of importance for the lives and output of late-baroque artists of Italy.
In economic theory, Lione promulgated a mix of protectionism and mercantilism, proposing the abolition of internal tariffs on agricultural products, and ban on the export of raw commodities and importationation of manufactured goods.
Lione was influenced by French economists such as Pierre Le Pesant. His work influenced later reforms implemented by Pope Pius VI and the Grand-Duke of Tuscany, Peter Leopold.
After his death, his heirs dispersed many of the works. About forty paintings form part of the collection of the Municipal Art Gallery of the town of Deruta, Italy.