Her career began under the patronage of Cardinal Marcantonio Barbarigo, who entrusted her with the work of founding schools for young women, especially the poor. The young ladies of Montefuscione were taught domestic arts, weaving, embroidering, reading, and Christian doctrine. Twelve years later the Cardinal devised a set of rules to guide Lucy and her followers in the religious life.
Fifty-two schools were established during Lucy"s lifetime.
Pope Clement XI, in 1707, called Lucy to Rome to start schools which he placed under his special protection. She died of breast cancer in 1732, aged 60, at Montefiascone.
Her statue can be seen in the south nave of Saint Peter"s Basilica.