As a child, she lived in Caracas and Miami, Florida, until moving to Los Angeles as a teenager. She is the older sister of actress Marieh Delfino. Actress
Delfino was cast in Metro-Goldwyn-Mayer"s "Zues & Roxanne" before landing the role of Tina Dimeo in National Broadcasting Company"s "The Tony Danza Show" where she played Tony Danza"s teenage daughter.
After playing Natalie Sanford in the indie darling "The Secret Life of Girls" Delfino was cast as Maria DeLuca on Roswell.
On hiatus she performed in the small role of Vanessa in Traffic as well as Natalie in The Secret Life of Girls. She also acted in Reeseville, Celeste in the City, The Tony Danza Show, and in R.S.V.P.
She played Trudi in the film State"s Evidence, which covers the topic of violence in schools. Delfino starred in a number of episodes of the National Broadcasting Company show Quarterlife, also shown on MySpaceTV, which started airing November 11, 2007.
As of June 2011, she was starring with Raven-Symoné in the show State of Georgia on the American Broadcasting Company Family channel till its cancellation.
Delfino performed in American Broadcasting Company"s pilot The Family Trap starring Mandy Moore and Stockard Channing. National Broadcasting Company did not greenlight the series. Delfino last starred in Columbia Broadcasting System"s "Friends With Better Lives" where they wrote her second pregnancy into the story line.
Delfino sang in several Roswell episodes, such as "Viva Las Vegas", "Cry Your Name", and "Behind the Music".
In the summer of 2000, Delfino released three songs onto the internet, "Siren", "Bruises" and "Tattoo", and wrote and produced them in association with "Sciences-Fi Lullaby". On October 31, 2001, Delfino released the European Parliament The Sicks on her own label, Dripfeed, without radio or television airplay.
Producer/remixer Justin Lassen created an 11-remix suite with Delfino"s masters from The Sicks that was never fully released due to red tape. Her second album, Tarte, was released on April 23, 2007, by her own record company, Red Velvet Cake Records, through her Web site www.majandra.com and can now be purchased through iTunes along with The Sicks.
In February 2011, the singer announced, through her Twitter, that she is working on her third studio album, scheduled for a late 2011 release.