She was a daughter of Count Dietrich VIII of Cleves and Margaret of Guelders, who was a daughter of Reginald I of Guelders. In 1333, her father issued an inheritance law, which said that after his death, the County of Cleves should fall to Margaret and her sisters Elisabeth and Maria.
Adolf II, Margaret"s husband, died in 1346, before her father died. Her eldest son, Engelbert III succeeded as Count of the Marck. John died in 1368. After his death, the Count of the Marck could finally assert their right to inherit Cleves.
Adolph and Margaret of Cleves had seven children:
Engelbert III (28 February 1333-Wetter 22 December 1391), married:
in 1354 to Richardis of Jülich (d 1360), a daughter of William V, Duke of Jülich
in 1381 Elisabeth of Sponheim-Sayn (d 1416), a daughter of Count Simon III of Vianden
Adolf III (1334 - 7 September 1394, Cleves), Archbishop of Cologne 1363-1364, later Count of Cleves and Count of the Marck
Dietrich (1336-1325 May 1406), bishop of Liège 1389, from which post he later resigned.
Eberhard (1341-after 1360), priest at Münster. Margareta (-12 September 1409), married John I, Count of Nassau-Dillenburg
Mechtild (-after 18 October 1390), married Eberhard of Isenburg-Grenzau.
Elisabeth, married Gumprecht of Heppendorf.
